Nampons™ are clinically proven to stop nosebleeds fast

Nampons contain a proprietary and patented active micro-dispersed oxidized cellulose that stops anterior bleeding fast. Oxidized cellulose has been used for over 50 years by millions of hospitals and first responders to help stop mild to moderate bleeding.

Efficacy

In 2017, a comprehensive study of nasal plugs impregnated with oxidized cellulose was performed over a two year period was published in the Netherlands by Dr. teGrotenhuis.  The paper, titled "Use of Hemostatic Nasal Plugs in Emergency Medical Services In The Netherlands" concluded that the nasal plugs is an effective adjunct in the prehospital treatment of severe and uncontrolled epistaxis (nosebleeds).

Furthermore, initial clinical studies performed in 1999-2000 in the Czech Republic examined the hemostatic power containing oxidized cellulose in surgical applications. This trial was a multicenter, randomized trial involving >200 patients. A number of different surgical procedures were used for this evaluation including maxillofacial surgery, general abdominal surgery, thoracic surgery, pulmonary surgery and Aesthetic surgery. This trial randomly divided all the patients into two with sterile contained oxidized cellulose in powdered for applied to treat bleeding in half the patients with normal surgical bleeding procedures and the control group just used normal surgical bleeding procedures. As expected, from a safety perspective no adverse events were reported. A significant result was found in this trial that observed a reduction (p<0.001) in bleeding when oxidized cellulose was used.

How Nampons™ stop the bleed

When applied to a wound, a number of effects occur.  First, the oxidized cellulose found in Nampons™ physically retards the blood flow, slowing down the bleed.  In addition, the SMOC™ technology in Nampons™ provides a surface or scaffold for proteins and cells in the blood to bind to and interact with, which greatly promotes quicker blood clotting.

Secondly, SMOC™ absorbs water and swells to form a gel-like structure.  This combined with the binding of large proteins and cells in the blood effectively create a "plug, " which acts as a physical barrier to bleeding.

Lastly, SMOC™ activates platelets in the blood.  These activated platelets aggregate, which significantly reduce the clotting time of blood and hence, stops the bleed.

Publications

  • “The influence of intrinsic coagulation pathway on blood platelets activation by oxidized cellulose.” J Biomed Mater Res A. 2007 Aug;82(2):274-80. Krízová P, Másová L, Suttnar J, Salaj P, Dyr JE, Homola J, Pecka M.
  • “Hemostyptic effect of oxidized cellulose on blood platelets.” Sb Lek. 2003;104(2):231-6.Masova L, Rysava J, Krizova P, Suttnar J, Salaj P, Dyr JE, Homola J, Dostalek J, Myska K, Pecka M.
  • “Surface interactions of oxidized cellulose with fibrin(ogen) and blood platelets.” Sensors and Actuators B 90 (2003) 243–249. J. Rysˇava ́a, J.E. Dyra, J. Homolab, J. Dosta ́lekb, P. Krˇı ́zˇova ́a, L. Ma ́sˇova ́a, J. Suttnara, J. Briestensky ́c, I. Santarc, K. Mysˇkac, M. Peckad
  • “In vitro and in vivo immunomodulatory effects of microdispersed oxidized cellulose. “ Int Immunopharmacol. 2002 Sep;2(10):1429-41. Jelinkova M, Briestensky J, Santar I, Rihova B.